Browsing UW Milwaukee Electronic Theses and Dissertations by Author "A. Andrew Pacheco"

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Impact of the Pre-a Motif on Truncated Hemoglobin N Activity

Drena, Alexander Shayne (2023-05-01)

Tuberculosis (TB) remains the leading cause of death by an infectious agent and therefore a global health crisis, according to the most recent report by the World Health Organization. This is due, in part, to Mycobacterium ...
Mechanistic Study of Heme Protein-Mediated Nitric Oxide Dioxygenation Using Photolytically Produced Nitric Oxide

Koebke, Karl Joseph (2015-08-01)

The previously reported NO precursor [Mn(PaPy2Q)(NO)]ClO4 (1), where (PaPy2QH) is N,N-bis(2-pyridylmethyl)-amine-N-ethyl-2-quinoline-2-carboxamide, was synthesized and proven capable of producing as much as 180 µM NO when ...
Structural and Functional Characterization of Acetoacetate Decarboxylase-Like Enzymes

Mueller, Lisa (2016-08-01)

The acetatoacetate decarboxylase-like superfamily (ADCSF) is a largely unexplored group of enzymes that may be a potential source of new biocatalysts. Bioinformatic analysis has grouped these approximately 2000 enzymes ...
The Search for the Four-electron Reduced Intermediate in the Cytochrome C Nitrite Reductase (CCNIR) - Catalyzed Reduction of Nitrite

Mandella, Victoria Lynn (2023-05-01)

Although there are many nitrogen species in the nitrogen cycle, nitrite occupies a centralrole. Nitrite can either reduce to ammonium or dinitrogen or oxidize to nitrate. Ammonium and nitrate can be found in the environment; ...