TOXICITY, BIOCONCENTRATION AND METABOLISM OF SELECTED CHEMICALS IN AQUATIC ORGANISMS

Abstract

PROJECT OBJECTIVES

This study will provide information for an assessment of (1) the hazard po­tential of selected organic compounds for freshwater organisms, and (2) the use of aquatic organisms as biological screening tools for contaminants in human drinking water supplies. Specific objectives include:

Objective I: Determine LC50 concentrations of test compounds for selected fish and invertebrate species by acute toxicity tests.

Objective II: Estimate "no-effect" concentrations of test compounds for selected fish and invertebrate species by embryo-larval or life-cycle toxicity tests.

Objective III: Determine-rate of uptake, bioconcentration potential, and rate of elimination of selected compounds in fish tissue.

Objective IV: Characterize selected test compound metabolites in fish and invertebrate species.