Effects of the Kappa Agonist U69,593 on Naltrexone’s Discriminative Stimulus Effect in Subjects Given Chronic, Intermittent Sucrose Access

File(s)
Date
2019-05Author
Marek, Morgan A.
Schulz, Emily
Fruit, Nicholas A.
Vile, Oriana
Stutt, Hannah
Zajac, Jonathan W.P.
Dorn, Holly
Herzberg, Caitlin
Petrey, Alex
Rothbauer, Dylan
Brandt, Lucas J.
Jewett, David C.
Metadata
Show full item recordAbstract
Naltrexone (NTX) is a non-specific opioid antagonist that is comparable to naloxone (Narcan). Avena, Hoebel & colleagues (2004) demonstrated that rats given access to a chronic, intermittent sucrose solution have increased endorphin function. Our previous research has shown that rats given access to a 25% sucrose solution can discriminate NTX (0.1 mg/kg - 3.2 mg/kg) from saline in an operant procedure. We wondered if NTX’s discriminative stimulus effects are mediated by kappa-opioid receptors. To examine this, we used U69,593, a kappa-opioid receptor agonist in multiple discrimination testing procedures.
Subject
Naltrexone
Kappa opioid receptor
Discrimination learning
Rats
Posters
Department of Psychology
Permanent Link
http://digital.library.wisc.edu/1793/81231Description
Color poster with text, charts, and graphs.