Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas) Volume V

Abstract

The completion of this fifth volume of Acute Toxicities of Organic

Chemicals to Fathead Minnows (Pimephales promelas) marks a milestone for our QSAR research program. The five volumes contain original data from 777 acute toxicity tests using 651 different chemicals and encompassing 12 years of effort. In April, 1989, a new data file called ATOC (Acute Toxicity of Organic Chemicals) was added to the AQUIRE (Aquatic Information Retrieval) data base currently available on-line to government agencies. The ATOC file contains test data on 525 of the 651 chemicals contained in volumes I-V of Acute

Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas). Other supplemental information has been added to the data base in the past two years and is reflected in the present volume. Individual tests from volumes I-V were reanalyzed for 24-, 48- and 72-hr LC50s (concentrations causing 50% mortality of the fish) and EC50s (concen­trations causing 50% of the fish to show an adverse effect). The results are recorded in Appendix C. Another component of the QSAR research program at ERL-D has been the study of behavioral toxicity syndromes. Of the chemicals contained in volumes I-V, 309 were evaluated using behavioral and morphological signs of stress which occurred during acute toxicity testing (Drwnmond and Russom 1990). The goal of that study was to classify chemicals according to general mode of action, and the chemicals used are listed in Appendix A. Cumulative appendices containing molecular formulas, GAS numbers and chemical names have been updated and are reported herein (Appendices A and B). Fathead minnow acute toxicity testing conducted at ERL-D and the University of Wisconsin-Superior has slowed somewhat in the last couple ofyears due to changing emphases in research. Emphasis has shifted towards early-life stage tests and the use of the medaka (Oryzias latipes) as a test organism. Volume V of the toxicity data base series incorporates all additional fathead minnow acute toxicity test data to date. It is anticipated that the future volumes will be published less frequently because the number of chemicals tested each year will decline. Although the level of fathead minnow acute toxicity testing has changed, the commitment of supplying the scientific community with high quality data will remain steadfast.

Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas). Other supplemental information has been added to the data base in the past two years and is reflected in the present volume. Individual tests from volumes I-V were reanalyzed for 24-, 48- and 72-hr LC50s (concentrations causing 50% mortality of the fish) and EC50s (concen­ trations causing 50% of the fish to show an adverse effect). The results are recorded in Appendix C. Another component of the QSAR research program at ERL-D has been the study of behavioral toxicity syndromes. Of the chemicals contained in volumes I-V, 309 were evaluated using behavioral and morphological signs of stress which occurred during acute toxicity testing (Drwnmond and Russom 1990). The goal of that study was to classify chemicals according to general mode of action, and the chemicals used are listed in Appendix A. Cumulative appendices containing molecular formulas, GAS numbers and chemical names have been updated and are reported herein (Appendices A and B). Fathead minnow acute toxicity testing conducted at ERL-D and the