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    Zebrafish, Genes, and Human Kidneys : Gene Mapping in Zebrafish Mutants May Help Uncover Genetic Roots of Polycystic Kidney Disease

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    PaulichSpr19-2.pdf (278.0Kb)
    PaulichSpr19-2.pptx (6.779Mb)
    Date
    2019-05
    Author
    Paulich, Katie
    Schleusner, Megan
    Johnson, Anneka L.
    Gingerich, Jamie Lyman
    Metadata
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    Abstract
    Patients with autosomal dominant polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. Current treatments for the disease manage cyst growth but do not prevent cyst formation. Although the specific genes that underlie polycystic kidney disease have been identified, the intervening steps between the altered gene and the disease symptoms remain in completely defined. The Lyman Gingerich lab studies polycystic kidney disease using the model organism Danio rerio, the zebrafish. Spinner mutant zebrafish develop kidney cysts and may be a good model for understanding cystic kidney disease.
    Subject
    Polycystic kidney disease (PKD)
    Zebrafish
    Posters
    Department of Biology
    Permanent Link
    http://digital.library.wisc.edu/1793/81044
    Type
    Presentation
    Description
    Color poster with text, images, charts, and photographs.
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