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Do IRX3 and IRX5 Direct Cytoplasm Traffic Between Oocytes During Germline Cyst Breakdown?
(2023)
Poor oocyte quality and a diminished ovarian reserve contribute significantly to female
infertility. The ovarian reserve is determined by the finite supply of primordial follicles a woman
has at birth. Evidence suggests ...
Investigating the Binding Specificity of Polymorphic KIR Alleles with Potential Ligands
(2023)
Natural killer (NK) cells are an important part of the immune response and play a
vital role in the defense against viral pathogens. NK cell function is characterized by its
ability to regulate cytotoxicity and modulate ...
Investigation of the Contribution of the Stimulator of Interferon Genes (STING) Pathway to the Type I interferon response in Murine glioblastoma cell lines
(2023)
Glioblastoma Multiforme (GBM) is a potent type of cancer due to its high mortality and aggressive nature with a median survival of 14 months post-diagnosis (1, 2). Immunotherapies are a promising approach to treating GBMs ...
The Prevalence of Clostridium difficile in the Wisconsin Area and the Role of Dietary Fiber on Colonization
(2020-05)
Clostridium difficile is an opportunistic pathogen. Since antibiotics alter a human’s microbiota, hospitalized patients are more likely to become infected with C. difficile. Studies have shown that a high-fiber diet can ...
Peripartal treatment with high-dose sertraline increases the RankL/Opg ratio and leads to negative offspring outcomes
(2022)
Clinical depression is common during pregnancy and postpartum, impacting 16%
of pregnant women and 20% of postpartum women . SSRIs are used to treat peripartal
depression; however, little is known about long-term effects ...
NF1 ALTERNATIVELY SPLICED EXON EXPRESSION CHANGES DURING SCHWANN CELL DIFFERENTIATION FROM MESENCHYMAL STEM CELLS
(2022)
Neurofibromatosis Type 1 (NF1) is a complex, yet relatively common, monogenic
disorder that can lead to a variety of detrimental phenotypes. However, the mechanisms behind
these manifestations of the disease are still ...
The role of the integrated stress response pathway on amino acid regulation of murine lactation
(2021)
Essential amino acids are the substrate for milk protein synthesis in the mammary gland. However, some amino acids play a supplementary role by signaling on cellular pathways that regulate lactation. The integrated stress ...
IMPROVING CRYOPRESERVATION METHODS USING CHOLESTEROL TO MODIFY CELL MEMBRANES
(2022)
Genomic testing has shifted the typical age distribution of bulls used for artificial
insemination to younger bulls (1). However, younger bulls produce less sperm than mature bulls,
creating a lack in supply to satisfy ...
Investigation of the Physiological Changes Behind the Range Expansion of the Polyploid Hybrid, Polystichum scopulinum
(2022)
In plants, polyploidy has been thought to play a key role in evolution as it can generate
more genetic variation. However, we do not have a strong understanding of how
polyploidy affects physiology, which limits our ...
Towards Profiling of G protein-biased Ligands of the Parathyroid hormone 1 receptor using a Streamlined Bioluminescence-based Binding
(2021)
We have generated and characterized a NanoLuc-parathyroid hormone 1 receptor (PTH1R) fusion protein that enables improved equilibrium and kinetic competition binding assays. We examined both the truncated endogenous ...