Many large- and small-scale changes occur in the genomes of tumor cells. The optical mapping system was used previously to discover structural variations (OSAs; Optical Structural Alterations) in tumor genomes. OSAs are ...

Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that has shown efficacy in numerous cancer types. Clinical data suggests that patients whom initially respond to cetuximab eventually acquire ...

Through previous studies, it has been found that Zebrafish embryos show a predictable pattern of cell division consisting of the spindle apparatus always aligning perpendicular to its orientation in the previous cell stage. ...

Intemeurons are important cellular components in the brain and they are mainly responsible for inhibitory actions in the central nervous system. Investigation of how intemeurons develop is necessary to understand neuronal ...

The Hedgehog (Hh) signaling pathway plays a crucial role in modulating embryonic development. Malfunctions in the vertebrate Hh pathway involving Sonic Hedgehog Homolog (Shh) have been linked to cancers including basal ...

Mutated SETX, a human gene encoding for the protein Senataxin, has been identified among patients with two different neurodegenerative disorders--ataxia-ocular apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4). ...

Our previous studies demonstrated that anti-CD40 mAb (anti-CD40) can synergize with CpG oligodeoxynucleotides (CpG) to mediate antitumor effects by activating myeloid cells such as macro phages in tumor-bearing mice. ...

Aleutian mink disease virus (AMDV) is a member of the parvoviridae family which primarily affects mink, often resulting in death. Nine viral genomes were amplified in segments using polymerase chain reactions (PCR) and ...

Anxiety is an incapacitating disorder affecting millions of people that emerges early in life. Past research has focused primarily on behavioral and neurophysiological differences in children and adults and has only recently ...

Induced Pluripotent Stem Cells are somatic cells that have been reprogrammed to acquire the properties of embryonic stem cells by the overexpression of various proteins. These somatic cells have acquired pluripotency by ...