Many large- and small-scale changes occur in the genomes of tumor cells. The optical mapping system was used previously to discover structural variations (OSAs; Optical Structural Alterations) in tumor genomes. OSAs are ...

Through previous studies, it has been found that Zebrafish embryos show a predictable pattern of cell division consisting of the spindle apparatus always aligning perpendicular to its orientation in the previous cell stage. ...

Mutated SETX, a human gene encoding for the protein Senataxin, has been identified among patients with two different neurodegenerative disorders--ataxia-ocular apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4). ...

Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...

Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...

It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ...