• Investigation of the Contribution of the Stimulator of Interferon Genes (STING) Pathway to the Type I interferon response in Murine glioblastoma cell lines 

  Kumari, Ria (2023)

  Glioblastoma Multiforme (GBM) is a potent type of cancer due to its high mortality and aggressive nature with a median survival of 14 months post-diagnosis (1, 2). Immunotherapies are a promising approach to treating GBMs ...

• Investigating the Binding Specificity of Polymorphic KIR Alleles with Potential Ligands 

  Alam, Fiza (2023)

  Natural killer (NK) cells are an important part of the immune response and play a vital role in the defense against viral pathogens. NK cell function is characterized by its ability to regulate cytotoxicity and modulate ...

• Do IRX3 and IRX5 Direct Cytoplasm Traffic Between Oocytes During Germline Cyst Breakdown? 

  Lansing, Lauren (2023)

  Poor oocyte quality and a diminished ovarian reserve contribute significantly to female infertility. The ovarian reserve is determined by the finite supply of primordial follicles a woman has at birth. Evidence suggests ...

• Towards Profiling of G protein-biased Ligands of the Parathyroid hormone 1 receptor using a Streamlined Bioluminescence-based Binding 

  Nguyen, Kevin (2021)

  We have generated and characterized a NanoLuc-parathyroid hormone 1 receptor (PTH1R) fusion protein that enables improved equilibrium and kinetic competition binding assays. We examined both the truncated endogenous ...

• Investigation of the Physiological Changes Behind the Range Expansion of the Polyploid Hybrid, Polystichum scopulinum 

  Lin, Lucas (2022)

  In plants, polyploidy has been thought to play a key role in evolution as it can generate more genetic variation. However, we do not have a strong understanding of how polyploidy affects physiology, which limits our ...

• NF1 ALTERNATIVELY SPLICED EXON EXPRESSION CHANGES DURING SCHWANN CELL DIFFERENTIATION FROM MESENCHYMAL STEM CELLS 

  Kumar, Rashmi (2022)

  Neurofibromatosis Type 1 (NF1) is a complex, yet relatively common, monogenic disorder that can lead to a variety of detrimental phenotypes. However, the mechanisms behind these manifestations of the disease are still ...

• The role of the integrated stress response pathway on amino acid regulation of murine lactation 

  Halderson, Steven (2021)

  Essential amino acids are the substrate for milk protein synthesis in the mammary gland. However, some amino acids play a supplementary role by signaling on cellular pathways that regulate lactation. The integrated stress ...

• IMPROVING CRYOPRESERVATION METHODS USING CHOLESTEROL TO MODIFY CELL MEMBRANES 

  Evans, Olivia (2022)

  Genomic testing has shifted the typical age distribution of bulls used for artificial insemination to younger bulls (1). However, younger bulls produce less sperm than mature bulls, creating a lack in supply to satisfy ...

• Peripartal treatment with high-dose sertraline increases the RankL/Opg ratio and leads to negative offspring outcomes 

  Bell, Autumn (2022)

  Clinical depression is common during pregnancy and postpartum, impacting 16% of pregnant women and 20% of postpartum women . SSRIs are used to treat peripartal depression; however, little is known about long-term effects ...

• The Prevalence of Clostridium difficile in the Wisconsin Area and the Role of Dietary Fiber on Colonization 

  Chao, Olivia (2020-05)

  Clostridium difficile is an opportunistic pathogen. Since antibiotics alter a human’s microbiota, hospitalized patients are more likely to become infected with C. difficile. Studies have shown that a high-fiber diet can ...

• GBT440 increases hematocrit and improves biventricular function in Berkeley sickle cell disease mice 

  Gassner, Ryan (2020-05)

  Sickle cell disease (SCD) is a hereditary blood disorder affecting millions of people in which red blood cells become sickled and lyse easily driven by polymerization of hemoglobin. Chronically, SCD causes anemia and ...

• A Quantitative Analysis of Proteomic Changes in Hippocampal Tissue of Alzheimer's Patients vs. Aged-Controls 

  Martinka, Levi (2018-06-12)

  The purpose of this study was to identify changes in protein expression that occur in the hippocampus in Alzheimer's disease (AD). To achieve this, we performed a quantitative analysis comparing the protein levels from ...

• The impact of social support on hospital utilization patterns of older adults with multiple chronic conditions: a qualitative study 

  Loosen, Julia (2018-06-12)

  Five percent of the US population accounts for half of all health care costs. Members of this high-need, high-cost population are likely to be older, have multiple chronic conditions (MCC), and face complex social conditions. ...

• Bacterial strains within the fungus gardens of leaf-cutter ants show evidence of mutual and commensal interactions 

  Dumar, Zach (2017-06-13)

  Leaf-cutter ants have a symbiotic relationship with a fungal cultivar known as Lecuoagaricus gongylophorus. The cultivar functions as an external gut by breaking down plant polysaccharides and supplies the ants with simple ...

• The Emotional Body: The Intersection Between Embodied Emotional Awareness, Empathy, Alexithymia, Well-Being and Altruism 

  Patel, Kush (2017-05-15)

  Emotion regulation and empathy are critical components for human social interaction and may help determine who is resilient when faced with challenging psychosocial situations and who may be vulnerable. Recent evidence has ...

• Investigating the Role of Kdm3b in the Acquisition of Pluripotency 

  Diny, Michael (2017-05-15)

  Induced Pluripotent Stem Cells are somatic cells that have been reprogrammed to acquire the properties of embryonic stem cells by the overexpression of various proteins. These somatic cells have acquired pluripotency by ...

• The role of vab-1/Eph receptor during epidermal intercalation in C.elegans 

  Cochran, Hunter (2017-05-15)

  During C. elegans embryo genesis, dorsal intercalation occurs when epidermal cells exchange places with one another. In this study, we describe a role for Eph receptor--a receptor tyrosine kinase, known as VAB-1 in C. ...

• Roles of Zic2 and Zic3 in early development 

  Fox, Dan (2017-05-08)

  The Hedgehog (Hh) signaling pathway plays a crucial role in modulating embryonic development. Malfunctions in the vertebrate Hh pathway involving Sonic Hedgehog Homolog (Shh) have been linked to cancers including basal ...

• Numerical Understanding in Mind, Brain, and Education Relations (N.U.M.B.E.R.) 

  Day, Danielle (2015-05-01)

  Past studies have demonstrated that non-human animals, infants and adult humans can process numerical information across multiple sensory modalities, and that number decisions are more accurate when number presented in ...

• AXL mediates the nuclear translocation of EGFR 

  Corrigan, Kelsey (2015)

  Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that has shown efficacy in numerous cancer types. Clinical data suggests that patients whom initially respond to cetuximab eventually acquire ...

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