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    Synthesis and Antibody Binding Study of MUC1 Mucin Peptides with Unnatural Backbones

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    File(s)
    SwensonSpr17.pdf (1.411Mb)
    SwensonSpr17.pptx (2.400Mb)
    Date
    2018-02-08
    Author
    Yang, Thao
    Swenson, Ryan D.
    Metadata
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    Abstract
    The MUC-1 mucin is a heavily glycosylated transmembrane protein found on the apical surface of epithelial cells with a short cytoplasmic end and a longer extracellular domain consisting of multiple 20-amino acid tandem repeats. The known roles of mucin protein include cell to cell interactions, protection of the cell, and lubrication of the cell’s surface. In tumor cells, the protein has alteration of its carbohydrate chains, thus exposing the core protein to the immune system, appearing as a foreign entity (1,2). This study is focused on synthesis of mucin peptides that have binding properties to the monoclonal antibody produced against the mucin from tumor cells.
    Subject
    Antibody binding
    Peptides
    Chemistry
    Mucin peptides
    Posters
    Permanent Link
    http://digital.library.wisc.edu/1793/77963
    Type
    Presentation
    Description
    Color poster with text, charts, and graphs.
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    • CERCA

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