The role of vab-1/Eph receptor during epidermal intercalation in C.elegans
MetadataShow full item record
During C. elegans embryo genesis, dorsal intercalation occurs when epidermal cells exchange places with one another. In this study, we describe a role for Eph receptor--a receptor tyrosine kinase, known as VAB-1 in C. elegans--during the process of intercalation. The literature suggests that vab-1 is crucial for proper embryogenesis; however, no one has described vab-l's role in intercalation specifically. Here, I show that VAB-1 is necessary for intercalation and determine which regions of the VAB-1 protein are required for intercalation using a variety of characterized alleles within the vab-1 gene. Because Eph receptors are highly conserved, this research has implications for vertebrate processes that depend on cell intercalation, such as neural tube closure.