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    The role of vab-1/Eph receptor during epidermal intercalation in C.elegans

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    Cochran.pdf (976.2Kb)
    Date
    2017-05-15
    Author
    Cochran, Hunter
    Advisor(s)
    Walck-Shannon, Elise
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    Abstract
    During C. elegans embryo genesis, dorsal intercalation occurs when epidermal cells exchange places with one another. In this study, we describe a role for Eph receptor--a receptor tyrosine kinase, known as VAB-1 in C. elegans--during the process of intercalation. The literature suggests that vab-1 is crucial for proper embryogenesis; however, no one has described vab-l's role in intercalation specifically. Here, I show that VAB-1 is necessary for intercalation and determine which regions of the VAB-1 protein are required for intercalation using a variety of characterized alleles within the vab-1 gene. Because Eph receptors are highly conserved, this research has implications for vertebrate processes that depend on cell intercalation, such as neural tube closure.
    Permanent Link
    http://digital.library.wisc.edu/1793/76475
    Type
    Thesis
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    • Biology Honors Theses and Research Papers

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