Browsing Student Research Day by Author "Zajac, Jonathan W.P."

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Calculation of Binding Free Energies of NAD(P)H:Quinone Oxidoreductase 1 Inhibitors

Bhattacharyya, Sudeep; Zajac, Jonathan W.P. (2018-04)

NAD(P)H:quinone oxidoreductase 1 (NQO1) plays a key role in cellular defense in humans. It is known to reduce quinones to hydroquinones, inhibiting their ability to become a free radical semiquinone state, and cause cellular ...
Effects of the Kappa Agonist U69,593 on Naltrexone’s Discriminative Stimulus Effect in Subjects Given Chronic, Intermittent Sucrose Access

Marek, Morgan A.; Schulz, Emily; Fruit, Nicholas A.; Vile, Oriana; Stutt, Hannah; Zajac, Jonathan W.P.; Dorn, Holly; Herzberg, Caitlin; Petrey, Alex; Rothbauer, Dylan; Brandt, Lucas J.; Jewett, David C. (2019-05)

Naltrexone (NTX) is a non-specific opioid antagonist that is comparable to naloxone (Narcan). Avena, Hoebel & colleagues (2004) demonstrated that rats given access to a chronic, intermittent sucrose solution have increased ...