Browsing Student Research Day by Author "Fehling, Samuel"

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Principal Component Analysis to Explore Transition Pathway of the Conformational Change in E. Faecalis Prolyl-tRNA Synthetase upon Substrate Binding

Fehling, Samuel; Strom, Alexander M. (2014-04)

Aminoacyl-tRNA synthetases (AARSs) catalyze the esterification of transfer RNAs with their cognate amino acids. These multi-domain enzymes undergo conformational changes upon substrate binding. To understand the molecular ...