Browsing Student Research Day by Author "Cao, Bach"
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Probing the Role of Highly Conserved Lysine (K279) Residue in the Editing Domain of Bacterial Prolyl-tRNA Synthetases
Mueller, Irene C.; Cao, Bach; Meitzner, Karl J.; Tschudy, Matthew J. (2011-05)The Escherichia coli (Ec) prolyl-tRNA synthetase enzyme possesses three distinct domains. One of the domains, the editing domain, is critical for proofreading the charged tRNAPro, ensuring the correct amino acid has been ... -
Role of Coupled Domain Motions on the Catalytic Activity of Escherichia coli Prolyl-tRNA Synthetase.
Cao, Bach; Greene, Alexander J.; Zimmerman, Kurt A. (2009-04)Prolyl-tRNA synthetases (ProRSs), which are class II synthetases that catalyze covalent attachment of proline to the 3'end of the tRNAPro. ProRSs from all three kingdoms of life, have shown to misactivate noncognate alanine ... -
Role of Protein Electronstatics on the Post-transfer Editing Function of Escherichia coli, Prolyl-tRNA Synthetase
Cao, Bach; Meitzner, Karl J.; Tschudy, Matthew J. (2010-04)Prolyl-tRNA synthetases (ProRSs) are class II synthetases that catalyze covalent attachment of proline to the 3'-end of the tRNAPro. ProRSs from all three kingdoms of life have shown to misactivate noncognate alanine and ...