Effects of Chlorpromazine in Rats Trained to Discriminate Between 2 and 22 Hr Food Deprivation

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Date
2012-04
Author
Dobbe, Jennifer E.
Donovan, Bryan A.
Hoida, Emily J.
Franklin, Bethany R.
Gomer, Bailey
Johnson, Amy R.
Michener, M.J.
Nelson, Courtney L.M.
Reed, Krystal A.
Van Asten, Ryan M.
Vargo, Joseph P.
Advisor(s)
Jewett, David C.
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Abstract
Chlorpromazine, a typical antipsychotic, has been shown to have varying effects on food intake. Chlorpromazine is a dopamine antagonist that blocks several dopamine receptors (including D1 and D2). Previous research indicated chlorpromazine (5.0mg/kg) may affect food intake in two time phases. This study looked at the effects of chlorpromazine in a food-deprivation discrimination paradigm that may serve as an animal model of 'hunger'.
Subject
Chlorpromazine--Side effects
Rats--Training
Discrimination learning
Hunger--Psychological aspects
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http://digital.library.wisc.edu/1793/61962
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