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dc.contributor.advisorGibson, Mark
dc.contributor.advisorGreany, John
dc.contributor.advisorFoster, Carl
dc.contributor.authorGehrke, Jessica
dc.date.accessioned2011-02-10T18:43:24Z
dc.date.available2011-02-10T18:43:24Z
dc.date.issued2010-06-14
dc.identifier.urihttp://digital.library.wisc.edu/1793/48324
dc.description.abstractBlood pressure typically decreases following exercise, a phenomenon known as postexercise hypotension (PEH). The cause of PEH is unclear but may include NO dependent mechanism. Men with erectile dysfunction are prescribed PDE-5 inhibitors to prevent the destruction of NO, thus producing a vasodilatory effect. Consumption of PDE-5 inhibitors may increase the effect of PEH by augmenting the effect of NO. This study compared PEH in active middle-aged men following heavy exercise with and without presence of a PDE-5 inhibitor (Sildenafil). Physically active men (mean age 54 + 13) performed 40 minutes of heavy exercise (~80 percent MHR) on two occasions, one hour following ingestion of either 50 mg of Sildenafil or placebo. Blood pressure was measured pre-exercise and immediately post-exercise at 10 minute intervals for 40 minutes. Blood pressure was significantly lower pre-exercise on Sildenafil 108 + 14 vs. 116 + 15 and decreased in parallel throughout post-exercise. PDE-5 inhibitors apparently increase the magnitude of reduced blood pressure both before and following heavy exercise. However, there is not an augmented response of PEH on PDE-5 inhibitors.en
dc.language.isoen_USen
dc.subjectBlood pressureen
dc.subjectExercise -- Physiological aspectsen
dc.subjectPhosphodiesterases -- Inhibitorsen
dc.titleEffect of PDE-5 inhibitors on post-exercise blood pressureen
dc.typeThesisen
thesis.degree.levelMSen
thesis.degree.disciplineClinical Exercise Physiologyen


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