Now showing items 1-10 of 10
Synthesis of Cyclic Antigenic MUC1 Mimotopes
The immune system responds to antigens via specific sequences called epitopes. The antibody binding amino acid epitope PDTRP within the variable tandem repeat (VNTR) domain of the Mucin1 (MUC1) transmembrane epithelial ...
Investigating Catalytically Important Residues in Escherichia coli Prolyl-tRNA Synthetase Through Site-Directed Mutagenesis
In the present study, we have employed site-directed mutagenesis to probe the role of four residues in E. coli ProRS (Ec ProRS) on the overall catalytic function. Specifically, we examined the impact of changes in amino ...
Structural and Energetic Properties of HN-GeFCH and Analogous Lewis Acid-Base Complexes (N-MX-R)
We are investigatingg molecular complexes that are prone to condensed-phase structural changes. A molecular complex, in general terms, is any association of two otherwise stable molecules.
Tuning Smart Properties of mPEG-block-PDMAEMA Through Polymer Composition
The purpose of this study was to study smart polymers. “Smart” polymers respond to changes in their environment with a measureable change in property. Some smart polymers can change their solubility when the conditions ...
Steric and Catalytic Effects of Alcohols on the Transamination of Napthalimides
This experiment describes a systematic study of the effects of the size of alcohols on the transamination of N-(3-chlorophenyl)-4-chloro-1,8- naphthalimide.
When Push Comes to Shove : Limitations of Hydrogen Bonded Liquid Crystal/Inhibitor Networks
A liquid crystal is state of matter that simultaneously displays properties of both a liquid and a solid. Liquid crystals have applications in liquid crystal displays (LCDs) and optical imaging technology. Liquid crystals ...
An IR and Computational Study of Pyridine-HCI and Its Fluorinated Analogs
Condensed phase effects on structure/bonding H-bonded complexes, e.g. HN-HCI, CHCN-HCI. A key issue is how medium effects affect extent of proton transfer. We are exploring pyridine and its fluorinated analogs as N ...
Optimizing the Sensitivity of Particulate Silica Quantification by Molybdenum Blue Absorbance Spectrometry
The purpose of this study was to develop a novel analytical method for quantifying respirable, airborne silicon containing particles.
Synthesis and Characterization of a Reversible and Tunable Smart Polymer
Polymers are made of covalently bonded repeat units, called monomers, which make up long chains. The structure can be controlled to achieve a diblock copolymer with two different repeat units connected in blocks. “Smart” ...
An Explanation of a-Cyanocinnamate Esters as a Replacement for DEAD in the Mitsunobu Reaction
The Mistunobu reaction was first reported by Oyo Mitsunobu in the Bulletin of the Chemical Society of Japanin 1967, with a follow-up review in Synthesisin 1981. A recent literature search using Web of Science reveals that ...