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Worms, Genetics and Healthy Kidneys : the Candidate PKD-2 Localization Factor, papl, May Play a Role in Polycystic Kidney Disease
Polycystic Kidney Disease (PKD) causes cysts to form within the kidneys, leading ultimately to renal failure. Prior research in our lab demonstrated that expression of the papl gene is downregulated in a zebrafish model ...
Zebrafish, Genes, and Human Kidneys : Gene Mapping in Zebrafish Mutants May Help Uncover Genetic Roots of Polycystic Kidney Disease
Patients with autosomal dominant polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. Current treatments for the ...
Studying the Effects of Extra Sets of Chromosomes on C. elegans Neurons : Using Tetraploid C. Elegans to Investigate Genetic Abnormalities
Polyploidy is a condition in which organisms possess multiple sets of chromosomes as a result of nondisjunction events during meiosis. In most organisms, polyploidy results in sterility or lethality, making it difficult ...
Elucidating the Role of Spinner in Cystic Kidneys : Using a Zebrafish Model to Better Understand Polycystic Kidney Disease
Patients with autosomal domain polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. There is no known cure and current ...
Polycystic Kidney Disease and Protein Localization : Analysis of the Role of gar-3 in Protein Localization to Cilia in Caenorhabditis Elegans
Gar-3, a gene that encodes a G protein-coupled acetylcholine receptor, has been shown to play roles in both neurotransmission and protein localization to synapses. We asked whether gar-3 also affects the localization of ...