Polycystic Kidney Disease (PKD) causes cysts to form within the kidneys, leading ultimately to renal failure. Prior research in our lab demonstrated that expression of the papl gene is downregulated in a zebrafish model ...

Patients with autosomal dominant polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. Current treatments for the ...

Polyploidy is a condition in which organisms possess multiple sets of chromosomes as a result of nondisjunction events during meiosis. In most organisms, polyploidy results in sterility or lethality, making it difficult ...

Patients with autosomal domain polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. There is no known cure and current ...

Genetic testing involves examining a patient's DNA sequence to look for changes (mutations) in the DNA that can potentially cause disease or illness. While some of the changes are benign, many have not yet been characterized ...

Gar-3, a gene that encodes a G protein-coupled acetylcholine receptor, has been shown to play roles in both neurotransmission and protein localization to synapses. We asked whether gar-3 also affects the localization of ...