Search
Now showing items 1-10 of 47
Analysis of the Antibody Binding of Derivative MUC1 Peptides via STD NMR
(2015-04)
This study analyzes the binding ability of the peptide GVTSAPD, an upstream sequence preceding PDTRP, as well as six derivative peptides against specific mouse MUC1 mucin monoclonal antibody (IgG1, 6A4) by Saturation ...
Purification of Copper-Free Methanobactin-SB2 to Analyze its Shape-Shifting Behavior
(2015-04)
We are interested in isolating the copper-free forms of methanobactin, which presents a challenge, since they are much more unstable and difficult to characterize than the copper bound forms that we and others have worked ...
Synthesis of Cyclic Antigenic MUC1 Mimotopes
(2017-12-01)
The immune system responds to antigens via specific sequences called
epitopes. The antibody binding amino acid epitope PDTRP within the variable
tandem repeat (VNTR) domain of the Mucin1 (MUC1) transmembrane
epithelial ...
Metal Sequestration During Aggregation Based Crystal Growth
(2018-01-09)
This project is focused on determining how associated metals of
environmental concern (especially Pb) behave during aggregationbased
crystal growth as a function of increasing Crystallinity Index (CI).
Synthesis and Antibody Binding Study of MUC1 Mucin Peptides with Unnatural Backbones
(2018-02-08)
The MUC-1 mucin is a heavily glycosylated transmembrane
protein found on the apical surface of epithelial cells with a
short cytoplasmic end and a longer extracellular domain
consisting of multiple 20-amino acid tandem ...
Smart Diblock Copolymers for Enhanced Oil Recovery Applications
(2015-04)
The purpose of this study was to examine the benefits and drawbacks of enhanced oil recovery (EOR).
Computational Docking of Mucin Peptide Derivatives with SM3 Antibody
(2018-05)
The crystal structure of the mucin monoclonal antibody SM3 complexed with a 13 amino acid MUC1 mucin peptide was determined. The high selectivity of the SM3 antibody to the aberrant carbohydrate cancer mucin peptide suggests ...
Investigating Catalytically Important Residues in Escherichia coli Prolyl-tRNA Synthetase Through Site-Directed Mutagenesis
(2017-11-30)
In the present study, we have employed
site-directed mutagenesis to probe the role of four residues in E. coli ProRS (Ec
ProRS) on the overall catalytic function. Specifically, we examined the impact of
changes in amino ...
Synthesis, Characterization and Applicability of Reactive Biomimetic Complexes Towards Important Biological Reactions
(2015-04)
This study involves the development, synthesis, and characterization of new biomimetic model systems consisting of a tetra-dentate N3[subscript]O-containing ligand (BPG) and divalent first-row transition metal ions observed ...
Quantum-Chemical Study of Hydrogen-Bonded Complexes : Understanding Solvent Shifts in the IR Spectra of Alcohols
(2015-04)
Initially, we were interested in whether the
hydrogen bonding in HF (l) or in H2O (l) is
stronger. Therefore, we examined a series of binary
complexes involving HF & H2O: (H2O)2, (HF)2, and three isomers of H2O/HF. We ...