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Exploring the Interplay of Dynamics and Catalysis in Escherichia coli Prolyl-tRNA Synthetase using Quantum Mechanical/Molecular Mechanical Simulations
The intrinsic dynamics that are inherent in proteins are known to be critical for many important biochemical processes. However, there is still limited information regarding how dynamics favor enzymes to achieve their ...
Investigating the Effects of Molecular Crowding on Protein Structure using Atomic Force Microscopy
To explore the structure-dynamics-function relationship in proteins, most studies are usually conducted in simple salt-buffer solutions, however, the interior of a cell is densely crowded. The concentration of macromolecular ...