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Molecular Dynamics Simulation Studies to Probe the Impact of Oxidative Stress on the Binding of SARS-CoV-2 Spike Protein to Angiotensin-Converting Enzyme 2

Fossum, Carl; Lowater, Harrison; Narkiewicz-Jodko, Alexander; Laatsch, Bethany; Lonzarich, Leo; Hati, Sanchita; Bhattacharyya, Sudeep (2021-04)

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein as well as the human cell surface receptor angiotensin-converting enzyme II (ACE2) contain several cysteine residues. These cysteine residues exist either in ...

How Does Varying Sizes and Concentrations of Poly(Ethylene Glycol) Affect the Conformation and Function of the Enzyme Escherichia Coli Prolyl-Trna Synthetase?

Liebau, Jessica; Laatsch, Bethany; Lowater, Harrison; Hati, Sanchita (2021-04)

Poly(ethylene glycol) (PEG) is a biocompatible, hydrophilic, flexible, non-toxic polyether commonly used in proteomics because it is widely regarded to be a biologically inert molecule. This includes PEG2000 (molecular ...