Now showing items 1-10 of 12
A Biographical Compendium of Organic Name Reactions
Name reactions are a mainstay of organic chemistry, and serve as a useful shorthand in discussions among organic chemists. These discussions usually focus on the reaction itself, and seldom include any significant consideration ...
Watching Life and Death at a Cellular Level
The purpose of this study was to show that the poorly-tolerated antifungal drug Amphotericin B (AmB) causes collateral damage in human cells in part by depolarizing (short-circuiting) mitochondria, the powerhouses of the cell.
Redox Chemistry of 9,10-diacetoxy-1,4-methano-1,4-dihydroanthracene Derivatives
The epoxide (2) of the title compound (1) has been found to have unusual oral anticoagulant activity in rats: At day 4 of co-administration with warfarin, it is a potent antagonist of anticoagulation; at day 10 of ...
Translation of Markovnikov’s Magistr Khimii Dissertation: A Progress Report
During June 2015, we were able to obtain digital copies of the Magistr Khimii and Doktor Khimii dissertations of Vladimir Vasil'evich Markovnikov. The translation of these documents into English consists of two distinct ...
Steric and Catalytic Effects of Alcohols on the Transamination of Napthalimides
This experiment describes a systematic study of the effects of the size of alcohols on the transamination of N-(3-chlorophenyl)-4-chloro-1,8- naphthalimide.
Progress Towards the Synthesis of Fluorescent Tröger’s bases With a Chiral Bridge
Julius Tröger first synthesized Tröger’s base in 1887. The compound is obtained by the reaction between formalin and p-toluidine in the presence of concentrated hydrochloric acid. The synthesis of the first fluorescent ...
Adventures with Fluorescent Compounds
4-Amino-1,8-naphthalimide derivatives1 are highly fluorescent compounds whose relatively simple synthesis and high quantum yields have led to their widespread use, for example, as fluorescent sensors for metal ions and pH, ...
Free Radical Mechanism for the Y-Glutamyl Carboxylase Reaction : A Computational Study
The purpose of this study was to discuss a combined energy profile for the radical mechanisms gamma-glutamyl carboxylase reaction. The initial step of the reaction mechanism involves a highly endothermic deprotonation of ...
3-Benzylidenecamphor Derivatives and Their Conversion Into Chiral Auxiliaries and Organocatalysts
The rigid camphor system with its well-defined geometry potentially possess all the key features required for a highly effective chiral auxiliary. This has been realized by Oppolzer, who devel¬oped three general exo-substituted ...
An Explanation of a-Cyanocinnamate Esters as a Replacement for DEAD in the Mitsunobu Reaction
The Mistunobu reaction was first reported by Oyo Mitsunobu in the Bulletin of the Chemical Society of Japanin 1967, with a follow-up review in Synthesisin 1981. A recent literature search using Web of Science reveals that ...