Now showing items 191-195 of 195
Defining the molecular determinants required for RNA binding functions of the Bicaudal-C (Bicc1) translational repressor protein
Bicaudal-C (Bicc1) is an RNA binding protein that functions as translational repressor in all animal species. Its repression activities are required for a multitude of biological processes such as guiding the earliest steps ...
Novel insight into the patterns of in vitro short abortive RNA release by Escherichia coli RNA polymerase
E. coli RNA polymerase (RNAP) catalyzes prokaryotic transcription with the σ70 specificity factor, which directs the binding of RNAP to promoter DNA. RNAP operates on the promoter to form an open complex. In transcription ...
Investigation of the Genome-Wide Distribution of Histone Variant H3.3
Epigenetic regulation via loci-specific deposition of variant histone proteins is important for genome stability and regulation of gene expression. Replication-independent histone variant H3.3 has been implicated in ...
GBT440 increases hematocrit and improves biventricular function in Berkeley sickle cell disease mice
Sickle cell disease (SCD) is a hereditary blood disorder affecting millions of people in which red blood cells become sickled and lyse easily driven by polymerization of hemoglobin. Chronically, SCD causes anemia and ...
Do Amazon Fulfillment Centers Help or Harm Local Economies?
In this paper, I investigate the Amazon Corporation’s impact on the economic well-being of the communities that house its warehouses, or “Fulfillment Centers.” A review of the literature surrounding Amazon’s economic impact ...