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ANTITUMOR EFFECTS OF ANTl-CD40/CPG IMMUNOTHERAPY COMBINED WITH GEMCIT ABINE OR 5-FLUOROURACIL CHEMOTHERAPY IN THE B 16 MELANOMA MODEL
Our previous studies demonstrated that anti-CD40 mAb (anti-CD40) can synergize with CpG oligodeoxynucleotides (CpG) to mediate antitumor effects by activating myeloid cells such as macro phages in tumor-bearing mice. ...
Activation and suppression of macrophages: implications for cancer immunotherapy
It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ...