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The role of offspring in mitigating extreme stress in lactating female mice
Mothers of many species find great comfort in their offspring, which in turn has been found to alleviate mild stress in the mother. In the face of a life-threatening event, however, do offspring still act as effective ...
Neuronal lysosome permeabilization dynamics in ischemia
The mechanism in which lysosomes are damaged by free radicals during neuronal ischemia is examined in rat hippocampus. There are two hypotheses. The free radicals can degrade the lysosome membrane through liquefaction; all ...
TRPV1 mediates matrix metalloproteinase expression in spinal cord injury-induced chronic neuropathic pain
Neuropathic pain (NP) is common following spinal cord injury (SCI). Evidence exists for the involvement of many processes in NP development following SCI (Cain et al, 2007). Our past studies identified increased expression ...
LEF/TCF family transcription factors are important in the upregulation and restricted expression of zic genes in the dorsal neural tube
A central question in biology is how different cell-types arise from an initially one-celled embryo to form an organism. Many cellular differences arise through differential gene expression in space and time via the action ...