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Inhibition of the Escherichia coli replication cycle by a mutant RecA protein
Abstract: A conserved [K/R]x[K/R] motif is found at the subunit-subunit interface in bacterial RecA protein filaments. In the Escherichia coli RecA protein, this motif is made up of residues K248 and K250. Both of these ...
The Role of PGC-1alpha in Adipocyte Differentiation and Fat Mobilization
Calorie Restriction (CR) without malnutrition extends mean and maximal lifespan in multiple species, although the mechanism is unknown. CR has a dramatic effect on adipose tissue morphology, gene expression and energy ...
The Biochemical Characterization of a Translational Repressor
Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...