College of Agricultural and Life Sciences, UW-Madison
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EGFR Signaling Promotes Invadosome-Mediated 3-D Axon Outgrowth
(2021)During development, axons and dendrites (collectively known as neurites) extend from neuron cell bodies to form appropriate synaptic connections, using secreted and cellsurface ligands as guides (Lowery & Vactor, 2009). ... -
Essential Amino Acids have Additive Effects on TORC1 in Bovine Mammary Epithelial Cells (MAC-T)
(2021)Milk proteins are produced in mammary epithelial cells from amino acids (AA). Excess AA that are not used for protein synthesis are excreted by the cow as nitrogenous (N) waste products through urine. Excretion of N waste ... -
Towards Profiling of G protein-biased Ligands of the Parathyroid hormone 1 receptor using a Streamlined Bioluminescence-based Binding
(2021)We have generated and characterized a NanoLuc-parathyroid hormone 1 receptor (PTH1R) fusion protein that enables improved equilibrium and kinetic competition binding assays. We examined both the truncated endogenous ... -
Genes, Neonatal Nursery and Biobehavioral Development
(2022)Evidence suggests that early life stress (ELS) has significant impacts on development and health. Neonatal intensive care unit (NICU) placement may be a form of ELS. Better understanding of the consequences and risk factors ... -
Investigation of the Physiological Changes Behind the Range Expansion of the Polyploid Hybrid, Polystichum scopulinum
(2022)In plants, polyploidy has been thought to play a key role in evolution as it can generate more genetic variation. However, we do not have a strong understanding of how polyploidy affects physiology, which limits our ... -
The Apoptotic Role of Cpeb1 in INS-1 Cells
(2022)The dedifferentiation of pancreatic (3-cells commonly occurs in the pathogenesis of both type 1 and type 2 diabetes. The (3-cell identity undergoes unique changes depending on the diabetogenic stress that is encountered. ... -
Testicular degeneration in a rat model expressing p.R106C TFG
(2021)Despite a majority of proteins depending on the early secretory pathway for export, the precise role of this machinery in development and maintenance of tissue architecture is largely unknown. The p.R106C mutation in ... -
NF1 ALTERNATIVELY SPLICED EXON EXPRESSION CHANGES DURING SCHWANN CELL DIFFERENTIATION FROM MESENCHYMAL STEM CELLS
(2022)Neurofibromatosis Type 1 (NF1) is a complex, yet relatively common, monogenic disorder that can lead to a variety of detrimental phenotypes. However, the mechanisms behind these manifestations of the disease are still ... -
The role of the integrated stress response pathway on amino acid regulation of murine lactation
(2021)Essential amino acids are the substrate for milk protein synthesis in the mammary gland. However, some amino acids play a supplementary role by signaling on cellular pathways that regulate lactation. The integrated stress ... -
Minicircle-Derived scn8ab Kock-In Reporter Line Provides a Model to Study Neuronal Regulation of Zebrafish Fin Regeneration
(2022)Understanding the cellular and molecular mechanisms of regenerative zebrafish will advance fundamental knowledge of tissue regeneration. Our previous study identified scn8ab, which encodes a voltage-gated sodium channel, ... -
The PrkA phosphosubstrate GpsB in Listeria monocytogenes promotes cell wall stress responses
(2021)None provided -
IMPROVING CRYOPRESERVATION METHODS USING CHOLESTEROL TO MODIFY CELL MEMBRANES
(2022)Genomic testing has shifted the typical age distribution of bulls used for artificial insemination to younger bulls (1). However, younger bulls produce less sperm than mature bulls, creating a lack in supply to satisfy ... -
Peripartal treatment with high-dose sertraline increases the RankL/Opg ratio and leads to negative offspring outcomes
(2022)Clinical depression is common during pregnancy and postpartum, impacting 16% of pregnant women and 20% of postpartum women . SSRIs are used to treat peripartal depression; however, little is known about long-term effects ... -
Single Nuclei RNA Sequencing of Mice Hippocampus to Evaluate in vivo Gene Editing by a Biodegradable Nanocage for CRISPR/Cas9 Ribonucleoproteins
(2021)In recent years, CRISPR-Cas9 technology has shown promise as a versatile gene editing tool that enables precise nucleotide base-editing (Sander & Joung, 2014), and are anticipated to drive the next wave of gene therapies ... -
Angiopoietin-2 Levels increase following Oxygen Glucose Deprivation (OGD) and Reperfusion in Brain Microvascular Endothelial Cells
(2022-02)Stroke is a leading cause of death, as onset induces an innate immune response using Toll-like receptor 4 (TLR4), which promotes inflammation and blood-brain barrier (BBB) permeability. TLR4 is a receptor for high-mobility ... -
Art Exhibit for Comprehension and Interest of Disease Ecology Research
(ASM Journals, Journal of Microbiology and Biology Education, 2023)Art is a common approach for communicating and educating about science, yet it remains unclear the extent to which science art can benefit varied audiences in varied contexts. To examine this gap, we developed an art exhibit ... -
Tadpole Pigmentation and Predation
(Elsevier, Environmental Pollution, 2022-06-09)Artificial light at night (ALAN) is a pervasive pollutant that influences wildlife at both the individual and community level. In this study, we tested the individual-level effects of ALAN on three species of tadpole prey ... -
Enrichment of Phospholipids by Enzymatic Hydrolysis and Membrane Filtration of Whey Protein Phospholipid Concentrate
(2022)Whey protein phospholipid concentrate (WPPC) contains high amounts of phospholipids (PL) (16.4 ± 3.6 % PL as % lipid) but there is interest in further enriching the PL content for nutritional and functional applications. ...
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